13 Chromosome
represents between 3.5% to 4% of the total DNA in cells. People normally
have two copies of this chromosome as all other non-sex chromosomes. Chromosome
thirteen spans about 114 million base pairs. Base Pairs are two molecules
(nucleotides) on opposite DNA strands that are connected. Adenine (A) forms a
base pair with thymine (T), as does guanine (G) with cytosine (C) in DNA. Base pairs is how DNA is measured.
There are about 551 genes in this chromosome.
Chromosome 13 has the
lowest gene density of the autosomes analysed to date. The genes present include
ones linked to various cancers and to schizophrenia. 105 putative non-coding RNA genes have also been
identified, including 9 microRNAs. Multi-species sequence comparison indicates
that over 95% of protein coding genes on the chromosome have been identified.
This analysis also reveals 112 non-exonic conserved regions, some of which could
be regulatory or structural elements.
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