4 Chromosome represents over 6% of DNA in cells. People normally have two copies of this chromosome as all other non-sex chromosomes. Chromosome four spans about 191 million base pairs. Base Pairs are two molecules (nucleotides) on opposite DNA strands that are connected. Adenine (A) forms a base pair with thymine (T), as does guanine (G) with cytosine (C) in DNA. Base pairs is how DNA is measured. There are about 1,154 genes in this chromosome.

Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for genes associated with Wolf-Hirschhorn syndrome, polycystic kidney disease and a form of muscular dystrophy.

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